109% lifespan extension, #1-ranked longevity coach, women's exercise advantage

Sponsored by

Welcome to the latest issue of The Longevity Newsletter, bringing you longevity news, breakthroughs, and evergreen truths to help you live longer and look younger.

Today, we have 109% in remaining lifespan of old mice… the coach of the #1-ranked Rejuvenation Olympian… women’s exercise advantage… and lots more. Let’s dig in.

LONGEVITY PARTNER OFFER

This Army Water Stops Urges

Too much water is NOT the cause of your bathroom struggles…

In fact, it’s the opposite. 

Kidneys don’t filter fluid as well as they did when you were a kid - causing concentrated urine that irritates your bladder and causes spontaneous urges.

Luckily, US Army researchers decoded a shockingly easy water trick that can improve muscle strength by 36%, reduce UTIs by 58%, and give you control back…

All by targeting the true cause of bladder problems in as little as 2 hours. 

> Try this simple Army water trick

GOOD FOR THE MICE DEPT.

Old mice live 109% longer and stronger with OSK

What's the news: Old wild mice live longer and stronger with OSK reprogramming.

Why should we believe it: This news is based on a new study published earlier this month by scientists at Rejuvenate Bio, a startup spun off from Harvard's Wyss Lab.

The scientists treated 124-week-old mice (equivalent to 77-year-old humans) with OSK. OSK is a treatment made up of 3 of the 4 rejuvenating Yamanaka factors that won the 2006 Nobel Prize. Results:

• Treated mice lived 109% longer than control mice (142 weeks vs. 133 weeks)

• Treated mice showed "significant improvement in frailty scores"

Why this is a big deal: OSK has already been shown to be a powerful rejuvenating intervention. But it was previously used with genetically modified mice, and with younger mice. This study shows significant results in wild-type mice, and in mice that had already accumulated a lot of mileage.

So what's next: Rejuvenate Bio recently signed a partnership to develop a "one-shot" gene therapy for dog osteoarthritis. That therapy uses a different technology than the one described in this study.

With this proof of concept of OSK in old wild mice, a trial in dogs seems like a likely next step. And beyond that? Let's hope for similar results in humans soon.

LAST WEEK’S POLL

Your attitude to fasting

Last week, I asked the readers of The Longevity Newsletter about their attitudes to fasting. This was in the wake of a new study that showed that the fasting-mimicking diet reduced biological age by 2.5 years after just 3 months.

A lot of readers voted. All types of fasting got some votes, but the overwhelming majority of respondent — 73% — said they practice intermittent fasting.

A few readers also expanded on their fasting practices. The most remarkable response I got came from a 98-year-old reader. He has been fasting every Thursday for 70 years, and he wrote:

IRREVOCABLY PERSONAL

David Haase, MD, coach to the #1-ranked Rejuvenation Olympian

Who we're talking about: Dr. David Haase, a double board-certified physician. Haase received his medical degree from Vanderbilt University School of Medicine and did his residency at the Mayo Clinic. Since 2003, he has headed MaxWell Clinic, a functional medicine clinic in Nashville, TN.

And the news is: One of Haase's patients at MaxWell Clinic, Dan Sullivan, is currently #1 on the Rejuvenation Olympics absolute leaderboard. Sullivan is 78 years old and is aging just 0.71 biological years for every chronological year. Whatever Haase is doing to Sullivan, it's working.

Why this is a big deal: As I've written before, scientists are making big progress teasing out the many complex mechanisms of aging on the molecular, genetic, and epigenetic levels. But what do all these results mean if you want to slow down or even reverse your biological age today?

Clinical practitioners, who work with actual people, have the best insights on that. And according to the Rejuvenation Olympics results, Haase is right at the top of that clinical practitioner group.

What's next? MaxWell Health offers 3 and 12 month programs for patients. In case you're interested, you can find more details here. And if you're not looking for a full-on longevity clinic, Haase also has a YouTube channel where he regularly posts news, shares advice, and holds webinars.

HAVE YOUR SAY

Your attitude to longevity clinics

Longevity clinics have been popping up around the country. Some are new. Some — like Dr. David Haase's MaxWell clinic, described above — have been around for decades.

AROUND THE WEB

Fasting masterclass (3 hours of hungry experts talking)

Deconstructing Dr. Steven Gundry

Hydrogen Water - Does It Actually Work?

Some excellent predictors of longevity

5-minute longevity lifestyle assessment

BELIEVE IT OR NOT

Women need half the exercise for same longevity benefit

What's the news: Women get the same exercise benefit as men with half the work.

Why should we believe it: This news is based on a new study published last week by scientists at Cedars-Sinai Medical Center. The study tracked a massive group of 412,413 adult participants. It looked at all-cause mortality and self-reported exercise habits. Results:

• Men who exercised 300 minutes per week reduced their risk of death the most, by 18%.

• Women got the same 18% reduction in mortality from just 140 minutes of weekly exercise.

• Women continued to get additional benefit up to the 300-minute mark.

Why this is an interesting result: This is an observational study. It cannot prove cause and effect. But it fits into what we already know — that regular exercise reduces mortality. It's just that some of us have it a little easier than others.

So what specifically can you do now: Exercise. This new study is not an excuse to cut down your exercise, but a motivation to start. Particularly if you're a woman — and even if you're a man — any amount of exercise will help you live longer and look younger.

I’ll leave you with that thought for this week. As always, thanks for reading The Longevity Newsletter. If you enjoyed this issue, consider forwarding it to someone who would find it interesting as well.

I'll be back in your inbox next Thursday, with more practical, inspiring, and fun news based on the latest in longevity science.

- The Longevity Hound