Skin aging reversed, brain health supplement, David Sinclair
Plus, advanced fat loss strategies

Welcome to the latest issue of The Longevity Newsletter, bringing you longevity news, breakthroughs, and evergreen truths to help you live longer and look younger.
Today, we have an intervention to reverse skin aging… a supplement for Alzheimer’s and Parkinson’s… David Sinclair’s new announcement… and more. Let’s dig in.
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If you are looking for a longevity supplement, then the Novos Core supplement subscription brings together the best ingredients in a total longevity package.
HUMAN BREAKTHROUGH DEPT.
Skin aging damage reversed with hyaluronic acid fillers

Not a good idea — but at least we can now reverse some of the damage
What's the news: Hyaluronic acid fillers reverse dermal changes caused by photoaging.
Why should we believe it: This news is based on a new study by scientists at the University of Michigan. They took 24 human subjects, aged 60+. The scientists then injected a popular dermal filler, cross-linked hyaluronic acid (HA). They examined the skin of the subjects after injecting the filler and found:
Within one week, skin cells went into action and started producing new collagen.
"Thick collagen bundles" were visible within 4 weeks
The results persisted at 12-month follow-up
Why this is a big deal: Hyaluronic acid fillers are a popular treatment offered by cosmetic clinics. The promise is that the filler smooths out wrinkles and fills out the face.
But as the current study shows, an HA filler is not simply filler, with no biological action. The hyaluronic acid actually reverses the breakdown of skin collagen that comes from photoaging.
So what specifically can you do now: The best way to deal with photoaging is still prevention. That means limited sun exposure and sunscreen for the times you are exposed.
But if you already have photoaged skin, and you want to reverse it, then consider hyaluronic acid fillers. As the current study shows, they are more than just a cosmetic bandaid. And the effects persist for a long time — the half-life of the newly formed collagen is 15 years.
LAST WEEK’S POLL
Your top-voted evergreen longevity topics
Last week, I asked the readers of The Longevity Newsletter about evergreen longevity topics that I should revisit regularly. A lot of readers voted. Here are the results:

The top-voted topics were brain health, weight loss, and skincare. I’ll definitely be revisiting these (as well as the other) evergreen topics in more depth in The Longevity Newsletter. In fact, let’s start right now, with…
EVERGREEN DEPT.
Lithium supplementation and good brain health

Studies show the Energizer Bunny keeps going and going thanks to constant lithium supplementation
Whats not news: Lithium is good for the brain, and even seems to increase longevity.
Why we should believe it: Evidence has been piling up for years. Most recently, a meta analysis published just last week summed up 29 relevant science papers, both in animals and humans. According to the meta-analysis, there is good evidence that supplemental lithium is a viable treatment for Alzheimer's disease and Parkinson's disease.
Previous studies in humans have shown that therapeutic levels of lithium increases gray matter in the brain. Therapeutic lithium (very high dose) also lowers risk of dementia, again in humans. It even reduces violent and antisocial behavior.
If that's not enough, a cross section study published in 2023 looked at 501,461 patients taking anti-psychotic medication. The study found that patients taking therapeutic lithium lived longer than those taking other anti-psychotic drugs.
So what can you specifically do now: There are no official daily recommendations for lithium supplementation. But a paper by the Director of the San Diego-based Biological Trace Element Research Institute recommends a dose of 1 mg of lithium per day.
Oddly, many lithium supplements contain doses that are either much lower or much higher doses than 1 mg. One good option that gives you exactly 1 mg of lithium is lithium ororate from Life Extension, a company that's been reviewed positively by third party labs such as labdoor.com and consumerlab.com.
HAVE YOUR SAY
Your attitude to dermal fillers
The lead story in today’s issue of The Longevity Newsletter talks about the collagen-restoring effects of hyaluronic acid dermal fillers. Does this news have you convinced? Intrigued? Repelled? In short…
What's your attitude to dermal fillers?Pick the choice below that best matches your attitude, and have your voice heard. I'll collect all the responses and publish them in next week's issue of The Longevity Newsletter: |
AROUND THE WEB
Intermittent rapamycin dosing vs. continuous
Could a single synthetic molecule outsmart a variety of drug-resistant bacteria?
The Real Life Diet of Longevity Doctor Mark Hyman, Who Developed a Six-Pack in His 60s (GQ)
Clinical trial shows rheumatoid arthritis drug could prevent disease
Advanced Fat Loss Strategies and Fat Loss Secrets (free webinar)
IRREVOCABLY PERSONAL
“1st epigenetic age reversal tech goes into humans next year”
Last year in April, biotech company Life Biosciences made big news. Life Bio was co-founded by Harvard’s David Sinclair, the pre-eminent star among longevity researchers. And last April, the company announced a breakthrough — they had used Yamanaka cellular rejuvenation to reverse blindness in monkeys.
Later last year, Life Bio CSO Sharon Rosenzweig-Lipson said Life Bio now has preclinical data for Alzheimer’s disease and frontotemporal dementia, as well as well as other eye disorders "including dry age-related macular degeneration, and other forms of retinal degeneration.”
And then earlier this month, David Sinclair himself tweeted the following:

The fact is, nobody knows for sure when we will have real, body-wide rejuvenation in humans. Maybe it will take decades, like that prediction above says. Or maybe, if David Sinclair is right, it will come much sooner than you expect.
But what is sure, at least in mind, is that this future is coming. That’s why each day matters. And why it makes sense to invest time, effort, and even money into your longevity today.
I’ll leave you with that thought for this week. As always, thanks for reading The Longevity Newsletter. If you enjoyed this issue, consider forwarding it to someone who would find it interesting as well.
I'll be back in your inbox next Thursday, with more practical, inspiring, and fun news based on the latest in longevity science.
- The Longevity Hound
